L25M (p.Leu25Met) variant of ARAF (P10398)
L25M (p.Leu25Met) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.68 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
L25M (p.Leu25Met) variant details
- p.Leu25Met
- gnomAD X-47563040-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.676
- REVEL 0.69
- CADD 23.80
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.971
- Literature evidence available