K22R (p.Lys22Arg) variant of ARAF (P10398)
K22R (p.Lys22Arg) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
K22R (p.Lys22Arg) variant details
- p.Lys22Arg
- gnomAD X-47563032-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.38
- REVEL 0.29
- CADD 18.40
- PolyPhen-2 0.02
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 2.4e-06)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.0695
- Literature evidence available