K22I (p.Lys22Ile) variant of ARAF (P10398)
K22I (p.Lys22Ile) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data, experimental measurements, and structural context.
K22I (p.Lys22Ile) variant details
- p.Lys22Ile
- ExAC rs746987091
- gnomAD rs746987091
- Missense
- Variant Prioritization Score for Impact Estimate 0.6
- REVEL 0.61
- CADD 27.10
- PolyPhen-2 0.91
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 2.9e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.0695