G6C (p.Gly6Cys) variant of ARAF (P10398)
G6C (p.Gly6Cys) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
G6C (p.Gly6Cys) variant details
- p.Gly6Cys
- gnomAD X-47562983-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.39
- REVEL 0.30
- CADD 23.40
- PolyPhen-2 0.24
- SIFT 0.09
- Population evidence available
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -1.01
- Literature evidence available