G53S (p.Gly53Ser) variant of ARAF (P10398)
G53S (p.Gly53Ser) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.78 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G53S (p.Gly53Ser) variant details
- p.Gly53Ser
- ExAC rs777093232
- gnomAD rs777093232
- Missense
- Variant Prioritization Score for Impact Estimate 0.783
- REVEL 0.83
- CADD 27.20
- PolyPhen-2 0.86
- SIFT 0.04
- Most common in the Latino/Admixed American population (allele frequency 2.8e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.377