G38R (p.Gly38Arg) variant of ARAF (P10398)
G38R (p.Gly38Arg) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.85 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G38R (p.Gly38Arg) variant details
- p.Gly38Arg
- TOPMed rs1210265001
- gnomAD rs1210265001
- Missense
- Variant Prioritization Score for Impact Estimate 0.85
- REVEL 0.94
- CADD 27.80
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 3.8e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.0822