G19S (p.Gly19Ser) variant of ARAF (P10398)
G19S (p.Gly19Ser) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
G19S (p.Gly19Ser) variant details
- p.Gly19Ser
- gnomAD X-47563022-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.486
- REVEL 0.34
- CADD 22.90
- PolyPhen-2 0.40
- SIFT 0.65
- Population evidence available
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.352
- Literature evidence available