G19D (p.Gly19Asp) variant of ARAF (P10398)
G19D (p.Gly19Asp) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G19D (p.Gly19Asp) variant details
- p.Gly19Asp
- cosmic curated COSV10961
- Ensembl rs2147902510
- Missense
- Variant Prioritization Score for Impact Estimate 0.604
- REVEL 0.54
- CADD 23.80
- PolyPhen-2 0.94
- SIFT 0.06
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.352