G11W (p.Gly11Trp) variant of ARAF (P10398)
G11W (p.Gly11Trp) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
G11W (p.Gly11Trp) variant details
- p.Gly11Trp
- gnomAD X-47562998-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.562
- REVEL 0.47
- CADD 23.40
- PolyPhen-2 0.72
- SIFT 0.01
- Most common in the East Asian population (allele frequency 3.4e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.35
- Literature evidence available