D46N (p.Asp46Asn) variant of ARAF (P10398)
D46N (p.Asp46Asn) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data, experimental measurements, and structural context.
D46N (p.Asp46Asn) variant details
- p.Asp46Asn
- cosmic curated COSV10640
- Missense
- Variant Prioritization Score for Impact Estimate 0.509
- REVEL 0.38
- CADD 23.60
- PolyPhen-2 0.93
- SIFT 0.49
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.41