A17S (p.Ala17Ser) variant of ARAF (P10398)
A17S (p.Ala17Ser) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data, experimental measurements, and structural context.
A17S (p.Ala17Ser) variant details
- p.Ala17Ser
- gnomAD rs1235882605
- Missense
- Variant Prioritization Score for Impact Estimate 0.225
- REVEL 0.22
- CADD 9.39
- PolyPhen-2 0.01
- SIFT 0.82
- Most common in the REMAINING population (allele frequency 2.2e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.319