T61S (p.Thr61Ser) variant of APP (Amyloid-beta precursor protein)
T61S (p.Thr61Ser) in APP (Amyloid-beta precursor protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data and structural context.
T61S (p.Thr61Ser) variant details
- p.Thr61Ser
- gnomAD rs11549661
- Missense
- Variant Prioritization Score for Impact Estimate 0.519
- REVEL 0.40
- CADD 17.10
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available