T22S (p.Thr22Ser) variant of APP (Amyloid-beta precursor protein)
T22S (p.Thr22Ser) in APP (Amyloid-beta precursor protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
T22S (p.Thr22Ser) variant details
- p.Thr22Ser
- ExAC rs761648158
- TOPMed rs761648158
- gnomAD rs761648158
- Missense
- Variant Prioritization Score for Impact Estimate 0.528
- REVEL 0.40
- CADD 21.00
- PolyPhen-2 0.01
- SIFT 0.35
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available