T163S (p.Thr163Ser) variant of APP (Amyloid-beta precursor protein)
T163S (p.Thr163Ser) in APP (Amyloid-beta precursor protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes population frequency data and structural context.
T163S (p.Thr163Ser) variant details
- p.Thr163Ser
- ExAC rs749504313
- gnomAD rs749504313
- Missense
- Variant Prioritization Score for Impact Estimate 0.538
- REVEL 0.50
- CADD 23.30
- PolyPhen-2 0.09
- SIFT 0.00
- Most common in the Ashkenazi Jewish population (allele frequency 5.1e-05)
- Structural context available