Q74L (p.Gln74Leu) variant of APP (Amyloid-beta precursor protein)
Q74L (p.Gln74Leu) in APP (Amyloid-beta precursor protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.83 / 1. The record also includes population frequency data and structural context.
Q74L (p.Gln74Leu) variant details
- p.Gln74Leu
- ExAC rs753737986
- Missense
- Variant Prioritization Score for Impact Estimate 0.828
- REVEL 0.93
- CADD 32.00
- PolyPhen-2 0.89
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 5e-05)
- Structural context available