P78T (p.Pro78Thr) variant of APP (Amyloid-beta precursor protein)
P78T (p.Pro78Thr) in APP (Amyloid-beta precursor protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.80 / 1. The record also includes population frequency data and structural context.
P78T (p.Pro78Thr) variant details
- p.Pro78Thr
- ExAC rs770493889
- TOPMed rs770493889
- gnomAD rs770493889
- Missense
- Variant Prioritization Score for Impact Estimate 0.802
- REVEL 0.93
- CADD 23.40
- PolyPhen-2 0.10
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 3.4e-06)
- Structural context available