M141V (p.Met141Val) variant of APP (Amyloid-beta precursor protein)
M141V (p.Met141Val) in APP (Amyloid-beta precursor protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.71 / 1. The record also includes population frequency data and structural context.
M141V (p.Met141Val) variant details
- p.Met141Val
- Ensembl rs200086074
- Missense
- Variant Prioritization Score for Impact Estimate 0.712
- REVEL 0.76
- CADD 27.40
- PolyPhen-2 0.47
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available