M141T (p.Met141Thr) variant of APP (Amyloid-beta precursor protein)
M141T (p.Met141Thr) in APP (Amyloid-beta precursor protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.79 / 1. The record also includes population frequency data and structural context.
M141T (p.Met141Thr) variant details
- p.Met141Thr
- ExAC rs745588837
- gnomAD rs745588837
- Missense
- Variant Prioritization Score for Impact Estimate 0.788
- REVEL 0.90
- CADD 26.20
- PolyPhen-2 0.89
- SIFT 0.01
- Most common in the 1KG:IBS population (allele frequency 0.017)
- Structural context available