K66R (p.Lys66Arg) variant of APP (Amyloid-beta precursor protein)
K66R (p.Lys66Arg) in APP (Amyloid-beta precursor protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.75 / 1. The record also includes population frequency data and structural context.
K66R (p.Lys66Arg) variant details
- p.Lys66Arg
- TOPMed rs1358123055
- gnomAD rs1358123055
- Missense
- Variant Prioritization Score for Impact Estimate 0.749
- REVEL 0.82
- CADD 27.80
- PolyPhen-2 0.96
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 4.5e-06)
- Structural context available