K66E (p.Lys66Glu) variant of APP (Amyloid-beta precursor protein)
K66E (p.Lys66Glu) in APP (Amyloid-beta precursor protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.79 / 1. The record also includes population frequency data and structural context.
K66E (p.Lys66Glu) variant details
- p.Lys66Glu
- ExAC rs778250646
- gnomAD rs778250646
- Missense
- Variant Prioritization Score for Impact Estimate 0.794
- REVEL 0.90
- CADD 27.30
- PolyPhen-2 0.96
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available