K161R (p.Lys161Arg) variant of APP (Amyloid-beta precursor protein)
K161R (p.Lys161Arg) in APP (Amyloid-beta precursor protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data and structural context.
K161R (p.Lys161Arg) variant details
- p.Lys161Arg
- Ensembl rs200892475
- Missense
- Variant Prioritization Score for Impact Estimate 0.478
- REVEL 0.40
- CADD 21.60
- PolyPhen-2 0.01
- SIFT 0.57
- Most common in the Non-Finnish European population (allele frequency 5.8e-05)
- Structural context available