K132T (p.Lys132Thr) variant of APP (Amyloid-beta precursor protein)
K132T (p.Lys132Thr) in APP (Amyloid-beta precursor protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.77 / 1. The record also includes population frequency data and structural context.
K132T (p.Lys132Thr) variant details
- p.Lys132Thr
- ExAC rs761373193
- gnomAD rs761373193
- Missense
- Variant Prioritization Score for Impact Estimate 0.775
- REVEL 0.85
- CADD 28.90
- PolyPhen-2 0.99
- SIFT 0.02
- Most common in the Finnish in Finland (FIN) population (allele frequency 3.8e-05)
- Structural context available