K132E (p.Lys132Glu) variant of APP (Amyloid-beta precursor protein)
K132E (p.Lys132Glu) in APP (Amyloid-beta precursor protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.76 / 1. The record also includes population frequency data and structural context.
K132E (p.Lys132Glu) variant details
- p.Lys132Glu
- TOPMed rs2045911693
- Missense
- Variant Prioritization Score for Impact Estimate 0.76
- REVEL 0.83
- CADD 29.20
- PolyPhen-2 0.96
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 2.3e-05)
- Structural context available