H110Q (p.His110Gln) variant of APP (Amyloid-beta precursor protein)
H110Q (p.His110Gln) in APP (Amyloid-beta precursor protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.69 / 1. The record also includes population frequency data and structural context.
H110Q (p.His110Gln) variant details
- p.His110Gln
- TOPMed rs202145222
- gnomAD rs202145222
- Missense
- Variant Prioritization Score for Impact Estimate 0.69
- REVEL 0.81
- CADD 23.80
- PolyPhen-2 0.45
- SIFT 0.00
- Most common in the 1KG:IBS population (allele frequency 0.017)
- Structural context available