G68D (p.Gly68Asp) variant of APP (Amyloid-beta precursor protein)
G68D (p.Gly68Asp) in APP (Amyloid-beta precursor protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
G68D (p.Gly68Asp) variant details
- p.Gly68Asp
- cosmic curated COSV61001
- TOPMed rs1307925400
- gnomAD rs1307925400
- Missense
- Variant Prioritization Score for Impact Estimate 0.454
- REVEL 0.34
- CADD 20.90
- PolyPhen-2 0.04
- SIFT 0.14
- Most common in the Non-Finnish European population (allele frequency 1.6e-05)
- Structural context available