D23N (p.Asp23Asn) variant of APP (Amyloid-beta precursor protein)
D23N (p.Asp23Asn) in APP (Amyloid-beta precursor protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data and structural context.
D23N (p.Asp23Asn) variant details
- p.Asp23Asn
- gnomAD rs1297968881
- Missense
- Variant Prioritization Score for Impact Estimate 0.547
- REVEL 0.39
- CADD 24.00
- PolyPhen-2 0.97
- SIFT 0.47
- Most common in the East Asian population (allele frequency 2.8e-05)
- Structural context available