C158Y (p.Cys158Tyr) variant of APP (Amyloid-beta precursor protein)
C158Y (p.Cys158Tyr) in APP (Amyloid-beta precursor protein) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes structural context.
C158Y (p.Cys158Tyr) variant details
- p.Cys158Tyr
- rs771319862
- NCI-TCGA Cosmic COSV6099
- cosmic curated COSV60994
- ExAC rs771319862
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.596
- AlphaMissense 1.00
- MetaLR 0.52
- MetaSVM 0.04
- PolyPhen-2 1.00
- SIFT 0.00
- EVE 0.72
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available