T105M (p.Thr105Met) variant of APOH (Beta-2-glycoprotein 1)
T105M (p.Thr105Met) in APOH (Beta-2-glycoprotein 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
T105M (p.Thr105Met) variant details
- p.Thr105Met
- ESP rs373470263
- ExAC rs373470263
- TOPMed rs373470263
- gnomAD rs373470263
- Missense
- Variant Prioritization Score for Impact Estimate 0.232
- REVEL 0.20
- AlphaMissense 0.08
- MetaLR 0.33
- MetaSVM -0.80
- CADD 14.20
- PolyPhen-2 1.00
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available