R21W (p.Arg21Trp) variant of APOH (Beta-2-glycoprotein 1)
R21W (p.Arg21Trp) in APOH (Beta-2-glycoprotein 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
R21W (p.Arg21Trp) variant details
- p.Arg21Trp
- ESP rs200237222
- ExAC rs200237222
- TOPMed rs200237222
- gnomAD rs200237222
- Missense
- Variant Prioritization Score for Impact Estimate 0.268
- REVEL 0.22
- CADD 22.80
- PolyPhen-2 0.73
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available