P85T (p.Pro85Thr) variant of APOH (Beta-2-glycoprotein 1)
P85T (p.Pro85Thr) in APOH (Beta-2-glycoprotein 1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
P85T (p.Pro85Thr) variant details
- p.Pro85Thr
- rs55645281
- NCI-TCGA Cosmic COSV5277
- gnomAD rs55645281
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.416
- AlphaMissense 0.15
- MetaLR 0.28
- MetaSVM -0.70
- PolyPhen-2 0.98
- SIFT 0.14
- EVE 0.37
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available