T26A (p.Thr26Ala) variant of APOE (Apolipoprotein E)
T26A (p.Thr26Ala) in APOE (Apolipoprotein E) is a missense change. Clinical records from ClinVar and UniProt describe it as likely benign in the context of Cardiovascular phenotype. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
T26A (p.Thr26Ala) variant details
- p.Thr26Ala
- Ensembl rs1969835105
- Likely benign
- Cardiovascular phenotype
- Missense
- Variant Prioritization Score for Impact Estimate 0.151
- REVEL 0.16
- CADD 0.26
- PolyPhen-2 0.00
- SIFT 0.85
- ClinVar: Likely benign (Cardiovascular phenotype)
- UniProt: Likely benign
- Most common in the Non-Finnish European population (allele frequency 5e-05)
- Structural context available