P28L (p.Pro28Leu) variant of APOE (Apolipoprotein E)
P28L (p.Pro28Leu) in APOE (Apolipoprotein E) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
P28L (p.Pro28Leu) variant details
- p.Pro28Leu
- ExAC rs764929617
- TOPMed rs764929617
- gnomAD rs764929617
- Missense
- Variant Prioritization Score for Impact Estimate 0.141
- REVEL 0.20
- CADD 0.22
- PolyPhen-2 0.00
- SIFT 0.23
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available