L46L (p.Leu46Leu) variant of APOE (Apolipoprotein E)
L46L (p.Leu46Leu) in APOE (Apolipoprotein E) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data, published literature, and structural context.
L46L (p.Leu46Leu) variant details
- p.Leu46Leu
- rs761381769
- gnomAD 19-44907854-G-A
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.285
- CADD 5.91
- Most common in the Middle Eastern population (allele frequency 0.0011)
- Structural context available
- Literature evidence available