G41S (p.Gly41Ser) variant of APOE (Apolipoprotein E)
G41S (p.Gly41Ser) in APOE (Apolipoprotein E) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
G41S (p.Gly41Ser) variant details
- p.Gly41Ser
- rs749406635
- ExAC rs749406635
- TOPMed rs749406635
- gnomAD rs749406635
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.151
- REVEL 0.20
- CADD 1.81
- PolyPhen-2 0.00
- SIFT 1.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available