F12Y (p.Phe12Tyr) variant of APOE (Apolipoprotein E)
F12Y (p.Phe12Tyr) in APOE (Apolipoprotein E) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
F12Y (p.Phe12Tyr) variant details
- p.Phe12Tyr
- ExAC rs747078681
- TOPMed rs747078681
- gnomAD rs747078681
- Missense
- Variant Prioritization Score for Impact Estimate 0.382
- REVEL 0.29
- CADD 23.80
- PolyPhen-2 0.07
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 2.3e-05)
- Structural context available