F12L (p.Phe12Leu) variant of APOE (Apolipoprotein E)
F12L (p.Phe12Leu) in APOE (Apolipoprotein E) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
F12L (p.Phe12Leu) variant details
- p.Phe12Leu
- TOPMed rs1381224336
- gnomAD rs1381224336
- Missense
- Variant Prioritization Score for Impact Estimate 0.285
- REVEL 0.28
- CADD 15.80
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available