E25D (p.Glu25Asp) variant of APOE (Apolipoprotein E)
E25D (p.Glu25Asp) in APOE (Apolipoprotein E) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data, published literature, and structural context.
E25D (p.Glu25Asp) variant details
- p.Glu25Asp
- gnomAD 19-44907791-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.267
- REVEL 0.13
- CADD 5.74
- PolyPhen-2 0.00
- SIFT 0.19
- Most common in the Ashkenazi Jewish population (allele frequency 5.1e-05)
- Structural context available
- Literature evidence available