L28F (p.Leu28Phe) variant of APOC3 (Apolipoprotein C-III)
L28F (p.Leu28Phe) in APOC3 (Apolipoprotein C-III) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
L28F (p.Leu28Phe) variant details
- p.Leu28Phe
- ExAC rs771868523
- TOPMed rs771868523
- gnomAD rs771868523
- Missense
- Variant Prioritization Score for Impact Estimate 0.514
- REVEL 0.42
- CADD 19.70
- PolyPhen-2 0.99
- SIFT 0.04
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available