V41M (p.Val41Met) variant of APOA5 (Apolipoprotein A-V)
V41M (p.Val41Met) in APOA5 (Apolipoprotein A-V) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of Cardiovascular phenotype. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
V41M (p.Val41Met) variant details
- p.Val41Met
- rs1941014617
- ClinGen CA382740989
- ClinVar RCV002368837
- Ensembl rs1941014617
- Likely benign
- Cardiovascular phenotype
- Missense
- Variant Prioritization Score for Impact Estimate 0.141
- REVEL 0.10
- CADD 2.02
- PolyPhen-2 0.00
- SIFT 0.44
- ClinVar: Likely benign (Cardiovascular phenotype)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available