F21L (p.Phe21Leu) variant of APOA1 (Apolipoprotein A-I)
F21L (p.Phe21Leu) in APOA1 (Apolipoprotein A-I) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
F21L (p.Phe21Leu) variant details
- p.Phe21Leu
- TOPMed rs1285743895
- gnomAD rs1285743895
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.267
- CADD 17.90
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the Latino/Admixed American population (allele frequency 2.8e-05)
- Structural context available