L75F (p.Leu75Phe) variant of ANGPTL3 (Angiopoietin-related protein 3)
L75F (p.Leu75Phe) in ANGPTL3 (Angiopoietin-related protein 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
L75F (p.Leu75Phe) variant details
- p.Leu75Phe
- ExAC rs768313034
- TOPMed rs768313034
- gnomAD rs768313034
- Missense
- Variant Prioritization Score for Impact Estimate 0.535
- REVEL 0.43
- CADD 24.70
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 0.00017)
- Structural context available