D25N (p.Asp25Asn) variant of ALPL (P05186)
D25N (p.Asp25Asn) in ALPL (P05186) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
D25N (p.Asp25Asn) variant details
- p.Asp25Asn
- rs766948855
- NCI-TCGA Cosmic COSV1008
- cosmic curated COSV10087
- NCI-TCGA Cosmic COSV6637
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.41
- REVEL 0.32
- CADD 18.10
- PolyPhen-2 0.01
- SIFT 0.79
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available