I163V (p.Ile163Val) variant of AKT3 (Q9Y243)
I163V (p.Ile163Val) in AKT3 (Q9Y243) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data.
I163V (p.Ile163Val) variant details
- p.Ile163Val
- gnomAD rs1680076274
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.472
- MetaLR 0.04
- MetaSVM -1.08
- CADD 22.30
- PolyPhen-2 0.06
- SIFT 0.00
- ClinVar: Uncertain significance (not provided)
- UniProt: Uncertain significance
- Most common in the African/African-American population (allele frequency 2.4e-05)