D3N (p.Asp3Asn) variant of AKT3 (Q9Y243)

Name: AKT3 D3N (p.Asp3Asn) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-08-21
License: https://catvariant.com/terms-of-use

D3N (p.Asp3Asn) in AKT3 (Q9Y243) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data.

D3N (p.Asp3Asn) variant details

p.Asp3Asn
Ensembl rs2148477566
NCI-TCGA Cosmic COSV9979
cosmic curated COSV99794
Variant assessed as somatic; moderate impact.
Missense
Variant Prioritization Score for Impact Estimate 0.599
MetaLR 0.23
MetaSVM -0.70
CADD 22.80
PolyPhen-2 0.01
SIFT 0.08
UniProt: Variant assessed as somatic; moderate impact.
Most common in the Non-Finnish European population (allele frequency 1.1e-05)