V74F (p.Val74Phe) variant of AKT2 (P31751)
V74F (p.Val74Phe) in AKT2 (P31751) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
V74F (p.Val74Phe) variant details
- p.Val74Phe
- ExAC rs754309980
- TOPMed rs754309980
- gnomAD rs754309980
- Missense
- Variant Prioritization Score for Impact Estimate 0.42
- REVEL 0.19
- CADD 22.90
- PolyPhen-2 0.28
- SIFT 0.04
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available