S92F (p.Ser92Phe) variant of AKT2 (P31751)
S92F (p.Ser92Phe) in AKT2 (P31751) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.72 / 1. The record also includes population frequency data and structural context.
S92F (p.Ser92Phe) variant details
- p.Ser92Phe
- rs764512283
- NCI-TCGA Cosmic COSV1002
- cosmic curated COSV10025
- ExAC rs764512283
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.719
- REVEL 0.67
- CADD 29.10
- PolyPhen-2 0.89
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available