V65L (p.Val65Leu) variant of AGTR1 (Type-1 angiotensin II receptor)
V65L (p.Val65Leu) in AGTR1 (Type-1 angiotensin II receptor) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
V65L (p.Val65Leu) variant details
- p.Val65Leu
- 1000Genomes rs111980524
- ESP rs111980524
- ExAC rs111980524
- TOPMed rs111980524
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.242
- REVEL 0.14
- CADD 19.20
- PolyPhen-2 0.04
- SIFT 0.01
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available