V35F (p.Val35Phe) variant of AGT (Angiotensinogen)
V35F (p.Val35Phe) in AGT (Angiotensinogen) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
V35F (p.Val35Phe) variant details
- p.Val35Phe
- ESP rs146773738
- ExAC rs146773738
- TOPMed rs146773738
- gnomAD rs146773738
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.312
- REVEL 0.18
- AlphaMissense 0.08
- MetaLR 0.16
- MetaSVM -0.85
- CADD 13.80
- PolyPhen-2 0.00
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available