R26W (p.Arg26Trp) variant of AGT (Angiotensinogen)
R26W (p.Arg26Trp) in AGT (Angiotensinogen) is a missense change. Clinical records from EBI and UniProt describe it as likely pathogenic. The available variant effect predictions contribute to a CATVariant prioritization score of 0.74 / 1. The record also includes population frequency data and structural context.
R26W (p.Arg26Trp) variant details
- p.Arg26Trp
- rs761670478
- ClinGen CA1448387
- NCI-TCGA Cosmic COSV1007
- ClinVar RCV001807665
- Likely pathogenic
- Missense
- Variant Prioritization Score for Impact Estimate 0.745
- AlphaMissense 0.42
- MetaLR 0.80
- MetaSVM 0.76
- PolyPhen-2 1.00
- SIFT 0.00
- EBI: Likely pathogenic
- UniProt: Likely pathogenic
- Population evidence available
- Structural context available