K66N (p.Lys66Asn) variant of AGT (Angiotensinogen)
K66N (p.Lys66Asn) in AGT (Angiotensinogen) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
K66N (p.Lys66Asn) variant details
- p.Lys66Asn
- rs773840793
- NCI-TCGA Cosmic COSV6418
- ExAC rs773840793
- TOPMed rs773840793
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.393
- AlphaMissense 0.13
- MetaLR 0.29
- MetaSVM -0.83
- PolyPhen-2 0.04
- SIFT 0.27
- MutPred 0.33
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available